Kadish staging: olfactory neuroblastoma, a clinical analysis of 17 cases
A Boston series of seventeen patients that proposed the three-stage system, based on whether the tumour is confined to the nose, involves the sinuses or has spread beyond them, still used to stage esthesioneuroblastoma today.
Overview
Clinical analysis of 17 patients with olfactory neuroblastoma (esthesioneuroblastoma) treated at the Massachusetts General Hospital, proposing stages A (tumour confined to the nasal cavity), B (nasal cavity and paranasal sinuses) and C (extension beyond the nasal cavity and sinuses), and reporting outcomes with surgery and radiotherapy.
The Kadish system, later modified with a stage D for nodal or distant metastasis, remains the most widely used staging scheme for this tumour.
- Three-stage system (A, B, C) by anatomical extent, with survival falling with stage.
The stage on an esthesioneuroblastoma page or pathology report is almost always a Kadish stage, and treatment intensity follows it.
- Seventeen patients from a single institution half a century ago.
- Does not incorporate Hyams histological grade, which is independently prognostic.