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The Japanese study in which the anti-CCR4 antibody mogamulizumab produced a response in half of people with relapsed adult T-cell leukaemia/lymphoma.
A multicentre phase 2 study of KW-0761 (mogamulizumab), a humanised defucosylated anti-CCR4 antibody that enhances antibody-dependent cellular cytotoxicity, in relapsed aggressive CCR4-positive adult T-cell leukaemia-lymphoma. Patients received 1.0 mg/kg intravenously once a week for eight weeks. The primary endpoint was overall response; secondary endpoints were progression-free and overall survival from the first dose.
The Japanese phase 2 evidence for mogamulizumab in relapsed disease; the 2019 international report records that the drug is approved in Japan for CCR4-positive adult T-cell leukaemia/lymphoma. The randomised study outside Japan later found a much lower confirmed response rate.
Shares CCR4, Mogamulizumab, Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares CCR4, Mogamulizumab, Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares Mogamulizumab phase 2 in relapsed adult T-cell leukaemia/lymphoma (Japan), CCR4, Mogamulizumab, Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares Mogamulizumab phase 2 in relapsed adult T-cell leukaemia/lymphoma (Japan), CCR4, Mogamulizumab, Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares Mogamulizumab phase 2 in relapsed adult T-cell leukaemia/lymphoma (Japan), Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares Adult T-cell leukaemia/lymphoma and the tag lymphoma-evidence-entities.
Shares Mogamulizumab phase 2 in relapsed adult T-cell leukaemia/lymphoma (Japan), Adult T-cell leukaemia/lymphoma.
Shares Mogamulizumab phase 2 in relapsed adult T-cell leukaemia/lymphoma (Japan), CCR4, Mogamulizumab.
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