RAINBOW: ramucirumab plus paclitaxel versus placebo plus paclitaxel in previously treated advanced gastric cancer
Adding the anti-VEGFR2 antibody ramucirumab to weekly paclitaxel lengthened survival by over two months in gastric cancer that had progressed after first-line chemotherapy, establishing the standard second-line regimen.
Overview
Phase 3 placebo-controlled trial of 665 patients with advanced gastric or junctional adenocarcinoma progressing after first-line platinum-fluoropyrimidine chemotherapy randomised to ramucirumab or placebo with weekly paclitaxel.
Median overall survival was 9.6 versus 7.4 months (hazard ratio 0.81), progression-free survival 4.4 versus 2.9 months and response 28 versus 16 percent; neutropenia, hypertension and fatigue were more frequent with ramucirumab.
- Median overall survival 9.6 vs 7.4 months; hazard ratio 0.81.
- Median progression-free survival 4.4 vs 2.9 months.
Ramucirumab-paclitaxel is the second-line standard for HER2-negative gastric cancer after chemo-immunotherapy, and the comparator for newer agents.
- Regional differences: benefit was smaller in Asian patients, partly because of more third-line therapy.
Similar pages
not linked directly; found by shared links- Key paperKEYNOTE-859: pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer
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