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A review of ten studies comparing radiotherapy plans for left breast cancer made in deep breath-hold and in free breathing. Breath-hold cut the average heart dose by up to 3.4 Gy, which on published dose-risk estimates corresponds to a 13.6 per cent smaller projected rise in heart disease risk.
Smyth and colleagues searched PubMed to July 2014 for studies comparing mean heart dose between deep inspiration breath-hold and free-breathing plans for left breast cancer. Ten studies provided data; breath-hold reduced the mean heart dose by up to 3.4 Gy. Four studies reported the technique was stable and reproducible day to day. Using current estimates of excess cardiac toxicity from radiotherapy, the authors calculated that a 3.4 Gy reduction is equivalent to a 13.6 per cent reduction in the projected increase in risk of heart disease.
The heart benefit of breath-hold is a projection from dose: it rests on the dose-risk relationship measured by Darby and colleagues, not on a trial counting heart attacks in women treated with and without breath-hold.
Shares Deep inspiration breath-hold (DIBH), Respiratory motion management (4D-CT, gating, breath-hold, tracking), HER2-positive breast cancer, Triple-negative breast cancer (TNBC) and the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
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