discovery
No description yet: the sentence for this tag has not been written. 4 records carry it: 4 people.
4 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
Gordon J. Freeman Professor of Medicine, Dana-Farber Cancer Institute and Harvard Medical School · Dana-Farber Brigham Cancer Center Showed that PD-L1 is the ligand for PD-1 and that the pair switches T cells off, the foundation of checkpoint immunotherapy. | none | none | immunotherapy, pd-1 | ||
Lieping Chen United Technologies Corporation Professor in Cancer Research, Yale School of Medicine · Yale School of Medicine / Yale Cancer Center Discovered PD-L1 (B7-H1) and showed tumours use it to escape immunity, the biology behind every anti-PD-1 drug. | none | none | immunotherapy, pd-l1 | ||
Shimon Sakaguchi Distinguished Professor, Immunology Frontier Research Center, Osaka University · Osaka University Graduate School of Medicine / Osaka University Hospital Discovered regulatory T cells, the immune cells that suppress anti-tumour responses and are now a target for cancer therapy. | none | none | immunology, regulatory-t-cells, japan | ||
Thomas Helleday Professor of Chemical Biology, Karolinska Institutet; Professor, University of Sheffield · Karolinska University Hospital Co-discovered that PARP inhibitors kill BRCA-deficient cells, the synthetic lethality behind olaparib and its successors. | none | none | parp, synthetic-lethality |
