epigenetic
No description yet: the sentence for this tag has not been written. 4 records carry it: 4 targets.
Related tags
4 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
EZH2 EZH2 EZH2 is an enzyme that silences genes. The first drug against it treated a rare sarcoma and some lymphomas until it was withdrawn in 2026 for causing second blood cancers. | Sarcomas, Prostate cancer, Diffuse large B-cell lymphoma | none | none | ||
Histone deacetylases (HDAC) HDAC1, HDAC2, HDAC3, HDAC6 Histone deacetylases tighten the packaging of DNA so that genes are switched off. Drugs that block them loosen the packaging and can wake up genes that make lymphoma cells stop growing or die. | Peripheral T-cell lymphomas, Multiple myeloma | none | none | ||
IDH1 / IDH2 IDH1, IDH2 A metabolic enzyme whose mutant form produces a molecule that scrambles how genes are read; blocking it slows brain tumours and leukaemias. | Glioma & glioblastoma, Acute myeloid leukaemia, Biliary tract cancer | none | driver | ||
Menin MEN1 A scaffold protein that certain leukaemias need to keep their genes switched on; the first drug against it was approved in 2024. | Acute myeloid leukaemia, Acute lymphoblastic leukaemia | none | none |