synthetic-lethality
No description yet: the sentence for this tag has not been written. 2 records carry it: 1 target, 1 person.
Related tags
2 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
PARP PARP1 PARP is a DNA repair enzyme. Cancers that have already lost one repair system (BRCA) die when this second one is blocked; healthy cells survive. | Ovarian cancer, Triple-negative breast cancer, HR-positive / HER2-negative breast cancer | none | none | ||
Thomas Helleday Professor of Chemical Biology, Karolinska Institutet; Professor, University of Sheffield · Karolinska University Hospital Co-discovered that PARP inhibitors kill BRCA-deficient cells, the synthetic lethality behind olaparib and its successors. | none | none | parp, discovery |
