ABI1
ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
ABI1 (Abl interactor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation.
- 3 · How drugs use it
No product in this corpus aims at ABI1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11320 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IZP0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136754 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: breast cancer 0.56 (GraphQL API, CC0))
Biology
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganisation and EGFR signalling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Location: Cytoplasm; Nucleus; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 10p12.1 (HGNC).
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ABI1" OR ABSTRACT:"ABI1" OR TITLE:"abl interactor 1" OR ABSTRACT:"abl interactor 1" OR TITLE:"Abl interactor 1" OR ABSTRACT:"Abl interactor 1" OR TITLE:"E3B1" OR ABSTRACT:"E3B1" OR TITLE:"ABI-1" OR ABSTRACT:"ABI-1" OR TITLE:"SSH3BP1" OR ABSTRACT:"SSH3BP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABI1, not a curated reading list.