ACTG1
ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
ACTG1 (Actin, cytoplasmic 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- 3 · How drugs use it
No product in this corpus aims at ACTG1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:144 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P63261 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184009 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17q25.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ACTG1" OR ABSTRACT:"ACTG1" OR TITLE:"actin gamma 1" OR ABSTRACT:"actin gamma 1" OR TITLE:"Actin, cytoplasmic 2" OR ABSTRACT:"Actin, cytoplasmic 2" OR TITLE:"DFNA20" OR ABSTRACT:"DFNA20" OR TITLE:"DFNA26" OR ABSTRACT:"DFNA26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTG1, not a curated reading list.