AGGF1
AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.89, animal model 0.41, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
AGGF1 (Angiogenic factor with G patch and FHA domains 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
- 3 · How drugs use it
No product in this corpus aims at AGGF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24684 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8N302 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164252 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Location: Cytoplasm; Secreted (UniProt). Locus 5q13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AGGF1" OR ABSTRACT:"AGGF1" OR TITLE:"angiogenic factor with G-patch and FHA domains 1" OR ABSTRACT:"angiogenic factor with G-patch and FHA domains 1" OR TITLE:"Angiogenic factor with G patch and FHA domains 1" OR ABSTRACT:"Angiogenic factor with G patch and FHA domains 1" OR TITLE:"VG5Q" OR ABSTRACT:"VG5Q" OR TITLE:"HSU84971" OR ABSTRACT:"HSU84971" OR TITLE:"FLJ10283" OR ABSTRACT:"FLJ10283") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGGF1, not a curated reading list.