AGTRAP
AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.89, animal model 0.26, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
AGTRAP (Type-1 angiotensin II receptor-associated protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation.
- 3 · How drugs use it
No product in this corpus aims at AGTRAP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:13539 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6RW13 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177674 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signalling by regulating receptor internalisation as well as mechanism of receptor desensitisation such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Location: Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle membrane (UniProt). Locus 1p36.22 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AGTRAP" OR ABSTRACT:"AGTRAP" OR TITLE:"angiotensin II receptor associated protein" OR ABSTRACT:"angiotensin II receptor associated protein" OR TITLE:"Type-1 angiotensin II receptor-associated protein" OR ABSTRACT:"Type-1 angiotensin II receptor-associated protein" OR TITLE:"ATRAP" OR ABSTRACT:"ATRAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AGTRAP, not a curated reading list.