AIMP2
AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
Overview
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
- 1 · What it is
AIMP2 (Aminoacyl tRNA synthase complex-interacting multifunctional protein 2) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer.
- 2 · What goes wrong in cancer
Required for assembly and stability of the aminoacyl-tRNA synthase complex.
- 3 · How drugs use it
No product in this corpus aims at AIMP2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:20609 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13155 (protein name, function text, keywords and locations (REST API)); CIViC gene AIMP2 (1 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer (GraphQL API, CC0))
Biology
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. Location: Cytoplasm, cytosol; Nucleus (UniProt). Locus 7p22.1 (HGNC).
- Lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AIMP2" OR ABSTRACT:"AIMP2" OR TITLE:"aminoacyl tRNA synthetase complex interacting multifunctional protein 2" OR ABSTRACT:"aminoacyl tRNA synthetase complex interacting multifunctional protein 2" OR TITLE:"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2" OR ABSTRACT:"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2" OR TITLE:"p38" OR ABSTRACT:"p38" OR TITLE:"PRO0992" OR ABSTRACT:"PRO0992" OR TITLE:"JTV-1" OR ABSTRACT:"JTV-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AIMP2, not a curated reading list.
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