ANO7
ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.73).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
ANO7 (Anoctamin-7) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity.
- 3 · How drugs use it
No product in this corpus aims at ANO7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:31677 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6IWH7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000146205 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.57 (GraphQL API, CC0))
Biology
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions. Location: Cell membrane; Cell junction; Endoplasmic reticulum; Cytoplasm, cytosol (UniProt). Locus 2q37.3 (HGNC).
- Prostate cancer: Open Targets association 0.57 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ANO7" OR ABSTRACT:"ANO7" OR TITLE:"anoctamin 7" OR ABSTRACT:"anoctamin 7" OR TITLE:"Anoctamin-7" OR ABSTRACT:"Anoctamin-7" OR TITLE:"PCANAP5L" OR ABSTRACT:"PCANAP5L" OR TITLE:"IPCA-5" OR ABSTRACT:"IPCA-5" OR TITLE:"PCANAP5" OR ABSTRACT:"PCANAP5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANO7, not a curated reading list.