AP3B1
AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.19, genetic association 0.00, somatic mutation 0.23, animal model 0.48).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
AP3B1 (AP-3 complex subunit beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes.
- 3 · How drugs use it
No product in this corpus aims at AP3B1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:566 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00203 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132842 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Location: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Golgi apparatus (UniProt). Locus 5q14.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"AP3B1" OR ABSTRACT:"AP3B1" OR TITLE:"adaptor related protein complex 3 subunit beta 1" OR ABSTRACT:"adaptor related protein complex 3 subunit beta 1" OR TITLE:"AP-3 complex subunit beta-1" OR ABSTRACT:"AP-3 complex subunit beta-1" OR TITLE:"ADTB3A" OR ABSTRACT:"ADTB3A" OR TITLE:"HPS2" OR ABSTRACT:"HPS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AP3B1, not a curated reading list.