ARHGEF5
ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.82, genetic association 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
ARHGEF5 (Rho guanine nucleotide exchange factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA.
- 3 · How drugs use it
No product in this corpus aims at ARHGEF5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:13209 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12774 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000050327 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: breast cancer 0.50 (GraphQL API, CC0))
Biology
Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organisation. Plays a role in actin organisation by generating a loss of actin stress fibres and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation. Location: Cytoplasm; Nucleus; Cell projection, podosome (UniProt). Locus 7q35 (HGNC).
- Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ARHGEF5" OR ABSTRACT:"ARHGEF5" OR TITLE:"Rho guanine nucleotide exchange factor 5" OR ABSTRACT:"Rho guanine nucleotide exchange factor 5" OR TITLE:"TIM1" OR ABSTRACT:"TIM1" OR TITLE:"GEF5" OR ABSTRACT:"GEF5" OR TITLE:"P60" OR ABSTRACT:"P60") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGEF5, not a curated reading list.