AXIN2
AXIN2 (Axin-2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer, Lung cancer and 2 more.
Overview
Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Vemurafenib and Cobimetinib. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.96, genetic association 0.87, somatic mutation 0.92, animal model 0.38).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · AXIN2 (Axin-2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer, Lung cancer and 2 more.
- 1 · What it is
AXIN2 (Axin-2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer, Lung cancer and 2 more.
- 2 · What goes wrong in cancer
Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin.
- 3 · How drugs use it
No product in this corpus aims at AXIN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:904 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y2T1 (protein name, function text, keywords and locations (REST API)); CIViC gene AXIN2 (2 evidence items, 0 assertions, 2 variants; diseases: Chronic Lymphocytic Leukaemia, Ganglioglioma (GraphQL API, CC0)); Open Targets ENSG00000168646 (association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: colorectal cancer 0.73, neuroendocrine neoplasm 0.51, skin cancer 0.54, lung cancer 0.53 (GraphQL API, CC0))
Biology
Inhibitor of the Wnt signalling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Location: Cytoplasm (UniProt). Locus 17q24.1 (HGNC).
- Colorectal cancer: Open Targets association 0.73 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
- Neuroendocrine tumours: Open Targets association 0.51 with neuroendocrine neoplasm (MONDO_0019496)
- Chronic lymphocytic leukaemia: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Ganglioglioma.
Latest papers
topQuery for this target: (TITLE:"AXIN2" OR ABSTRACT:"AXIN2" OR TITLE:"axin 2" OR ABSTRACT:"axin 2" OR TITLE:"Axin-2" OR ABSTRACT:"Axin-2" OR TITLE:"MGC126582" OR ABSTRACT:"MGC126582" OR TITLE:"DKFZp781B0869" OR ABSTRACT:"DKFZp781B0869") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AXIN2, not a curated reading list.
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