BAG4
BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.95, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
BAG4 (BAG family molecular chaperone regulator 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling.
- 3 · How drugs use it
No product in this corpus aims at BAG4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:940 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95429 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156735 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signalling. Negative regulator of PRKN translocation to damaged mitochondria. Location: Cytoplasm (UniProt). Locus 8p11.23 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BAG4" OR ABSTRACT:"BAG4" OR TITLE:"BAG cochaperone 4" OR ABSTRACT:"BAG cochaperone 4" OR TITLE:"BAG family molecular chaperone regulator 4" OR ABSTRACT:"BAG family molecular chaperone regulator 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BAG4, not a curated reading list.