C11orf65
C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
Overview
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.07, genetic association 0.91, somatic mutation 0.87).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
- 1 · What it is
C11orf65 (chromosome 11 open reading frame 65) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Colorectal cancer, Ovarian cancer and 4 more.
- 2 · What goes wrong in cancer
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.
- 3 · How drugs use it
No product in this corpus aims at C11orf65 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:28519 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NCR3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166323 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.62, gastric cancer 0.54, prostate cancer 0.54, urinary bladder cancer 0.53, ovarian cancer 0.55, non-Hodgkin lymphoma 0.54 (GraphQL API, CC0))
Biology
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network. Location: Cytoplasm, cytosol; Mitochondrion outer membrane (UniProt). Locus 11q22.3 (HGNC).
- Breast cancer: Open Targets association 0.65 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575)
- Ovarian cancer: Open Targets association 0.55 with ovarian cancer (MONDO_0008170)
- Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)
- Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"C11orf65" OR ABSTRACT:"C11orf65" OR TITLE:"chromosome 11 open reading frame 65" OR ABSTRACT:"chromosome 11 open reading frame 65" OR TITLE:"MGC33948" OR ABSTRACT:"MGC33948") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about C11orf65, not a curated reading list.