CARS1
CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
Overview
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys).
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.76, genetic association 0.00, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
- 1 · What it is
CARS1 (Cysteine--tRNA ligase, cytoplasmic) is an enzyme. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Lung cancer and Melanoma.
- 2 · What goes wrong in cancer
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CARS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:1493 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49589 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110619 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.50, skin cancer 0.54, lung cancer 0.50 (GraphQL API, CC0))
Biology
Catalyses the ATP-dependent ligation of cysteine to tRNA(Cys). Location: Cytoplasm (UniProt). Locus 11p15.4 (HGNC).
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)
- Melanoma: Open Targets association 0.50 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CARS1" OR ABSTRACT:"CARS1" OR TITLE:"cysteinyl-tRNA synthetase 1" OR ABSTRACT:"cysteinyl-tRNA synthetase 1" OR TITLE:"Cysteine--tRNA ligase, cytoplasmic" OR ABSTRACT:"Cysteine--tRNA ligase, cytoplasmic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CARS1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetMAP3K13
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetMRTFA
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetPER1
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetPHOX2B
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetNKX2-1
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetAFDN
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetATP2B3
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.
- TargetFCRL4
Shares Lung cancer (all types), Skin cancer (all types), Melanoma, Open Targets Platform.