CCDC170
CCDC170 (Coiled-coil domain-containing protein 170) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Plays a role in Golgi-associated microtubules organisation and stabilisation.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCDC170 (Coiled-coil domain-containing protein 170) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
CCDC170 (Coiled-coil domain-containing protein 170) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Plays a role in Golgi-associated microtubules organisation and stabilisation. Location: Golgi apparatus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CCDC170 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:21177 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IYT3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000120262 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0))
Biology
Plays a role in Golgi-associated microtubules organisation and stabilisation. Location: Golgi apparatus (UniProt). Locus 6q25.1 (HGNC).
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CCDC170" OR ABSTRACT:"CCDC170" OR TITLE:"coiled-coil domain containing 170" OR ABSTRACT:"coiled-coil domain containing 170" OR TITLE:"Coiled-coil domain-containing protein 170" OR ABSTRACT:"Coiled-coil domain-containing protein 170" OR TITLE:"FLJ23305" OR ABSTRACT:"FLJ23305" OR TITLE:"bA282P11.1" OR ABSTRACT:"bA282P11.1" OR TITLE:"C6orf97" OR ABSTRACT:"C6orf97") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC170, not a curated reading list.