CCNB1IP1
CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Overview
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.19, genetic association 0.00, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 1 · What it is
CCNB1IP1 (E3 ubiquitin-protein ligase CCNB1IP1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 2 · What goes wrong in cancer
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites.
- 3 · How drugs use it
No product in this corpus aims at CCNB1IP1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:19437 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPC3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100814 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: skin cancer 0.51 (GraphQL API, CC0))
Biology
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalisation of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. Location: Nucleus; Chromosome (UniProt). Locus 14q11.2 (HGNC).
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CCNB1IP1" OR ABSTRACT:"CCNB1IP1" OR TITLE:"cyclin B1 interacting protein 1" OR ABSTRACT:"cyclin B1 interacting protein 1" OR TITLE:"E3 ubiquitin-protein ligase CCNB1IP1" OR ABSTRACT:"E3 ubiquitin-protein ligase CCNB1IP1" OR TITLE:"HEI10" OR ABSTRACT:"HEI10" OR TITLE:"C14orf18" OR ABSTRACT:"C14orf18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCNB1IP1, not a curated reading list.