CCNE1
CCNE1 (G1/S-specific cyclin-E1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Ovarian cancer and 5 more.
Overview
Essential for the control of the cell cycle at the G1/S (start) transition.
CIViC holds 16 clinical evidence items and 0 assertions across 3 variants, naming Palbociclib, Dinaciclib, CDK Inhibitor SNS-032 and Camonsertib and others. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes affected pathway 0.57, literature 0.99, genetic association 0.57, somatic mutation 0.96, animal model 0.64). In OnCo, 1 product record names it (AVZO-021).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCNE1 (G1/S-specific cyclin-E1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Ovarian cancer and 5 more.
- 1 · What it is
CCNE1 (G1/S-specific cyclin-E1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Ovarian cancer and 5 more.
- 2 · What goes wrong in cancer
Essential for the control of the cell cycle at the G1/S (start) transition. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CCNE1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1589 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P24864 (protein name, function text, keywords and locations (REST API)); CIViC gene CCNE1 (16 evidence items, 0 assertions, 3 variants; diseases: Ovarian Cancer, Breast Cancer, Gastric Adenosquamous Carcinoma, Ovarian Carcinoma, Stomach Cancer and 4 more (GraphQL API, CC0)); Open Targets ENSG00000105173 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.58, gastric cancer 0.51, urinary bladder cancer 0.52, skin cancer 0.50, breast cancer 0.50 (GraphQL API, CC0))
Biology
Essential for the control of the cell cycle at the G1/S (start) transition. Location: Nucleus (UniProt). Locus 19q12 (HGNC).
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056); CIViC evidence names this disease
- Breast cancer: Open Targets association 0.50 with breast cancer (MONDO_0007254); CIViC evidence names this disease
- Ovarian cancer: CIViC evidence names this disease
- Endometrial cancer: CIViC evidence names this disease
- Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)
- Bladder & urothelial cancer: Open Targets association 0.52 with urinary bladder cancer (MONDO_0001187)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 10 therapies; CIViC holds 16 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Gastric Adenosquamous Carcinoma; Ovarian Serous Cystadenocarcinoma; Endometrial Serous Adenocarcinoma.
Latest papers
topQuery for this target: (TITLE:"CCNE1" OR ABSTRACT:"CCNE1" OR TITLE:"cyclin E1" OR ABSTRACT:"cyclin E1" OR TITLE:"G1/S-specific cyclin-E1" OR ABSTRACT:"G1/S-specific cyclin-E1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCNE1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetPOLQ
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