CD79A
CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
Overview
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
- 1 · What it is
CD79A (B-cell antigen receptor complex-associated protein alpha chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Non-Hodgkin lymphoma and Skin cancer.
- 2 · What goes wrong in cancer
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation.
- 3 · How drugs use it
No product in this corpus aims at CD79A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1698 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11912 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105369 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: colorectal cancer 0.53, non-Hodgkin lymphoma 0.51, skin cancer 0.50 (GraphQL API, CC0))
Biology
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalisation of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signalling during development of immature B-cells. Location: Cell membrane (UniProt). Locus 19q13.2 (HGNC).
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CD79A" OR ABSTRACT:"CD79A" OR TITLE:"CD79a molecule" OR ABSTRACT:"CD79a molecule" OR TITLE:"B-cell antigen receptor complex-associated protein alpha chain" OR ABSTRACT:"B-cell antigen receptor complex-associated protein alpha chain" OR TITLE:"MB-1" OR ABSTRACT:"MB-1" OR TITLE:"Ig-alpha" OR ABSTRACT:"Ig-alpha" OR TITLE:"MB1" OR ABSTRACT:"MB1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD79A, not a curated reading list.