CDA
CDA (Cytidine deaminase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms and Myelodysplastic syndromes / neoplasms.
Overview
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.84).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDA (Cytidine deaminase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms and Myelodysplastic syndromes / neoplasms.
- 1 · What it is
CDA (Cytidine deaminase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Myeloproliferative neoplasms and Myelodysplastic syndromes / neoplasms.
- 2 · What goes wrong in cancer
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Locus 1p36.12 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at CDA yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:1712 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P32320 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000158825 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: myelodysplastic syndrome 0.51, myeloproliferative neoplasm 0.53, leukaemia 0.53 (GraphQL API, CC0))
Biology
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Locus 1p36.12 (HGNC).
- Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.51 with myelodysplastic syndrome (MONDO_0018881)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.84. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDA" OR ABSTRACT:"CDA" OR TITLE:"cytidine deaminase" OR ABSTRACT:"cytidine deaminase" OR TITLE:"Cytidine deaminase" OR ABSTRACT:"Cytidine deaminase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDA, not a curated reading list.
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