ETNK1
ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
Overview
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.18, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
- 1 · What it is
ETNK1 (Ethanolamine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Breast cancer and Myeloproliferative neoplasms.
- 2 · What goes wrong in cancer
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
- 3 · How drugs use it
No product in this corpus aims at ETNK1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:24649 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HBU6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000139163 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: myeloproliferative neoplasm 0.51, breast cancer 0.51, leukaemia 0.52 (GraphQL API, CC0))
Biology
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. Location: Cytoplasm (UniProt). Locus 12p12.1 (HGNC).
- Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
- Myeloproliferative neoplasms: Open Targets association 0.51 with myeloproliferative neoplasm (MONDO_0020076)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ETNK1" OR ABSTRACT:"ETNK1" OR TITLE:"ethanolamine kinase 1" OR ABSTRACT:"ethanolamine kinase 1" OR TITLE:"Ethanolamine kinase 1" OR ABSTRACT:"Ethanolamine kinase 1" OR TITLE:"EKI1" OR ABSTRACT:"EKI1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETNK1, not a curated reading list.
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