ACTA2
ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Overview
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 1 · What it is
ACTA2 (Actin, aortic smooth muscle) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 2 · What goes wrong in cancer
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ACTA2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:130 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62736 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107796 (per-cancer scores at or above 0.5: leukaemia 0.53 (GraphQL API, CC0))
Biology
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 10q23.31 (HGNC).
- Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ACTA2" OR ABSTRACT:"ACTA2" OR TITLE:"actin alpha 2, smooth muscle" OR ABSTRACT:"actin alpha 2, smooth muscle" OR TITLE:"Actin, aortic smooth muscle" OR ABSTRACT:"Actin, aortic smooth muscle" OR TITLE:"ACTSA" OR ABSTRACT:"ACTSA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACTA2, not a curated reading list.