FGFR1OP2
FGFR1OP2 (FGFR1 oncogene partner 2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia.
Overview
May be involved in wound healing pathway.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.22, affected pathway 0.95, animal model 0.56, genetic association 0.03).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGFR1OP2 (FGFR1 oncogene partner 2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 1 · What it is
FGFR1OP2 (FGFR1 oncogene partner 2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 2 · What goes wrong in cancer
May be involved in wound healing pathway. Location: Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at FGFR1OP2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:23098 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NVK5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000111790 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: leukaemia 0.55 (GraphQL API, CC0))
Biology
May be involved in wound healing pathway. Location: Cytoplasm (UniProt). Locus 12p11.23 (HGNC).
- Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGFR1OP2" OR ABSTRACT:"FGFR1OP2" OR TITLE:"FGFR1 oncogene partner 2" OR ABSTRACT:"FGFR1 oncogene partner 2" OR TITLE:"DKFZp564O1863" OR ABSTRACT:"DKFZp564O1863") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGFR1OP2, not a curated reading list.