MYO18A
MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Overview
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.63, affected pathway 0.97, genetic association 0.00, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 1 · What it is
MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 2 · What goes wrong in cancer
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
- 3 · How drugs use it
No product in this corpus aims at MYO18A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:31104 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95411 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196535 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0))
Biology
Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MYO18A" OR ABSTRACT:"MYO18A" OR TITLE:"myosin XVIIIA" OR ABSTRACT:"myosin XVIIIA" OR TITLE:"Putative TGFB1-induced anti-apoptotic factor 1" OR ABSTRACT:"Putative TGFB1-induced anti-apoptotic factor 1" OR TITLE:"KIAA0216" OR ABSTRACT:"KIAA0216" OR TITLE:"MysPDZ" OR ABSTRACT:"MysPDZ" OR TITLE:"TIAF1" OR ABSTRACT:"TIAF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYO18A, not a curated reading list.