LRRFIP1
LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Overview
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.83, affected pathway 0.94, genetic association 0.37).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 1 · What it is
LRRFIP1 (Leucine-rich repeat flightless-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 2 · What goes wrong in cancer
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA.
- 3 · How drugs use it
No product in this corpus aims at LRRFIP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6702 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q32MZ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124831 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0))
Biology
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signalling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Location: Nucleus; Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LRRFIP1" OR ABSTRACT:"LRRFIP1" OR TITLE:"LRR binding FLII interacting protein 1" OR ABSTRACT:"LRR binding FLII interacting protein 1" OR TITLE:"Leucine-rich repeat flightless-interacting protein 1" OR ABSTRACT:"Leucine-rich repeat flightless-interacting protein 1" OR TITLE:"FLAP-1" OR ABSTRACT:"FLAP-1" OR TITLE:"FLIIAP1" OR ABSTRACT:"FLIIAP1" OR TITLE:"GCF-2" OR ABSTRACT:"GCF-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRRFIP1, not a curated reading list.