ACOXL
ACOXL (Acyl-coenzyme A oxidase-like protein) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
Overview
UniProt has no function text for Q9NUZ1; HGNC names it "acyl-CoA oxidase like".
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ACOXL (Acyl-coenzyme A oxidase-like protein) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 1 · What it is
ACOXL (Acyl-coenzyme A oxidase-like protein) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9NUZ1; HGNC names it "acyl-CoA oxidase like". Locus 2q13 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at ACOXL yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:25621 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NUZ1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000153093 (per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0))
Biology
UniProt has no function text for Q9NUZ1; HGNC names it "acyl-CoA oxidase like". Locus 2q13 (HGNC).
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ACOXL" OR ABSTRACT:"ACOXL" OR TITLE:"acyl-CoA oxidase like" OR ABSTRACT:"acyl-CoA oxidase like" OR TITLE:"Acyl-coenzyme A oxidase-like protein" OR ABSTRACT:"Acyl-coenzyme A oxidase-like protein" OR TITLE:"FLJ11042" OR ABSTRACT:"FLJ11042" OR TITLE:"ACOX4" OR ABSTRACT:"ACOX4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACOXL, not a curated reading list.