ARHGAP26
ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
Overview
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.92, genetic association 0.51, somatic mutation 0.90, animal model 0.32).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
- 1 · What it is
ARHGAP26 (Rho GTPase-activating protein 26) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Gastric & gastro-oesophageal junction cancer, Breast cancer, Leukaemia and 2 more.
- 2 · What goes wrong in cancer
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria.
- 3 · How drugs use it
No product in this corpus aims at ARHGAP26 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17073 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UNA1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145819 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.55, skin cancer 0.51, myeloproliferative neoplasm 0.52, breast cancer 0.54, leukaemia 0.54 (GraphQL API, CC0))
Biology
GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesised proteins. Location: Endosome membrane; Cytoplasm; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 5q31.3 (HGNC).
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.55 with gastric cancer (MONDO_0001056)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.52 with myeloproliferative neoplasm (MONDO_0020076)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ARHGAP26" OR ABSTRACT:"ARHGAP26" OR TITLE:"Rho GTPase activating protein 26" OR ABSTRACT:"Rho GTPase activating protein 26" OR TITLE:"Rho GTPase-activating protein 26" OR ABSTRACT:"Rho GTPase-activating protein 26" OR TITLE:"KIAA0621" OR ABSTRACT:"KIAA0621" OR TITLE:"OPHN1L" OR ABSTRACT:"OPHN1L" OR TITLE:"OPHN1L1" OR ABSTRACT:"OPHN1L1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGAP26, not a curated reading list.
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