LPP
LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
Overview
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites.
Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.93, animal model 0.56, genetic association 0.79, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
- 1 · What it is
LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.
- 2 · What goes wrong in cancer
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription.
- 3 · How drugs use it
No product in this corpus aims at LPP yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93052 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145012 (association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: gastric cancer 0.50, neuroendocrine neoplasm 0.50, non-Hodgkin lymphoma 0.52, skin cancer 0.63, basal cell carcinoma 0.57, breast cancer 0.57 (GraphQL API, CC0))
Biology
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Location: Nucleus; Cytoplasm; Cell junction; Cell membrane (UniProt). Locus 3q27.3-q28 (HGNC).
- Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)
- Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)
- Neuroendocrine tumours: Open Targets association 0.50 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LPP" OR ABSTRACT:"LPP" OR TITLE:"LIM domain containing preferred translocation partner in lipoma" OR ABSTRACT:"LIM domain containing preferred translocation partner in lipoma" OR TITLE:"Lipoma-preferred partner" OR ABSTRACT:"Lipoma-preferred partner") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LPP, not a curated reading list.
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