CDC37
CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.99, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CDC37 (Hsp90 co-chaperone Cdc37) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
- 3 · How drugs use it
No product in this corpus aims at CDC37 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1735 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16543 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105401 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Biology
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilisation and promotion of their activity. Inhibits HSP90AA1 ATPase activity. Location: Cytoplasm (UniProt). Locus 19p13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDC37" OR ABSTRACT:"CDC37" OR TITLE:"cell division cycle 37, HSP90 cochaperone" OR ABSTRACT:"cell division cycle 37, HSP90 cochaperone" OR TITLE:"Hsp90 co-chaperone Cdc37" OR ABSTRACT:"Hsp90 co-chaperone Cdc37" OR TITLE:"P50CDC37" OR ABSTRACT:"P50CDC37") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDC37, not a curated reading list.