CDC50A
CDC50A (Cell cycle control protein 50A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Overview
Accessory component of a P4-ATPase flippase complex which catalyses the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signalling molecules. The beta subunit may assist in binding of the phospholipid substrate.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming R-CHOP Regimen.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDC50A (Cell cycle control protein 50A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 1 · What it is
CDC50A (Cell cycle control protein 50A) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Accessory component of a P4-ATPase flippase complex which catalyses the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids.
- 3 · How drugs use it
No product in this corpus aims at CDC50A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16667 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NV96 (protein name, function text, keywords and locations (REST API)); CIViC gene CDC50A (2 evidence items, 0 assertions, 2 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Biology
Accessory component of a P4-ATPase flippase complex which catalyses the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signalling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:CDC50A flippase complex. ATP8A2:CDC50A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:CDC50A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Location: Membrane; Cell membrane; Golgi apparatus; Cytoplasmic vesicle, secretory vesicle membrane (UniProt). Locus 6q14.1 (HGNC).
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDC50A" OR ABSTRACT:"CDC50A" OR TITLE:"cell division cycle 50 P4-ATPase accessory subunit A" OR ABSTRACT:"cell division cycle 50 P4-ATPase accessory subunit A" OR TITLE:"Cell cycle control protein 50A" OR ABSTRACT:"Cell cycle control protein 50A" OR TITLE:"FLJ10856" OR ABSTRACT:"FLJ10856" OR TITLE:"C6orf67" OR ABSTRACT:"C6orf67" OR TITLE:"TMEM30A" OR ABSTRACT:"TMEM30A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDC50A, not a curated reading list.