CDKAL1
CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.72, animal model 0.46, genetic association 0.63).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CDKAL1 (Threonylcarbamoyladenosine tRNA methylthiotransferase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
- 3 · How drugs use it
No product in this corpus aims at CDKAL1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:21050 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5VV42 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145996 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Catalyses the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Location: Endoplasmic reticulum membrane (UniProt). Locus 6p22.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDKAL1" OR ABSTRACT:"CDKAL1" OR TITLE:"CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase" OR ABSTRACT:"CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase" OR TITLE:"Threonylcarbamoyladenosine tRNA methylthiotransferase" OR ABSTRACT:"Threonylcarbamoyladenosine tRNA methylthiotransferase" OR TITLE:"FLJ20342" OR ABSTRACT:"FLJ20342") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDKAL1, not a curated reading list.