CELF2
CELF2 (CUGBP Elav-like family member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CELF2 (CUGBP Elav-like family member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CELF2 (CUGBP Elav-like family member 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability.
- 3 · How drugs use it
No product in this corpus aims at CELF2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:2550 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95319 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000048740 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonising the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Location: Nucleus; Cytoplasm (UniProt). Locus 10p14 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CELF2" OR ABSTRACT:"CELF2" OR TITLE:"CUGBP Elav-like family member 2" OR ABSTRACT:"CUGBP Elav-like family member 2" OR TITLE:"Etr-3" OR ABSTRACT:"Etr-3" OR TITLE:"NAPOR-2" OR ABSTRACT:"NAPOR-2" OR TITLE:"BRUNOL3" OR ABSTRACT:"BRUNOL3" OR TITLE:"CUGBP2" OR ABSTRACT:"CUGBP2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CELF2, not a curated reading list.