CFLAR
CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Bicalutamide.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
CFLAR (CASP8 and FADD-like apoptosis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis.
- 3 · How drugs use it
No product in this corpus aims at CFLAR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1876 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15519 (protein name, function text, keywords and locations (REST API)); CIViC gene CFLAR (1 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Biology
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signalling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Locus 2q33.1 (HGNC).
- Prostate cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CFLAR" OR ABSTRACT:"CFLAR" OR TITLE:"CASP8 and FADD like apoptosis regulator" OR ABSTRACT:"CASP8 and FADD like apoptosis regulator" OR TITLE:"CASP8 and FADD-like apoptosis regulator" OR ABSTRACT:"CASP8 and FADD-like apoptosis regulator" OR TITLE:"Casper" OR ABSTRACT:"Casper" OR TITLE:"CLARP" OR ABSTRACT:"CLARP" OR TITLE:"FLAME" OR ABSTRACT:"FLAME") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CFLAR, not a curated reading list.