CNBP
CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.88, animal model 0.50, genetic association 0.00, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CNBP (CCHC-type zinc finger nucleic acid binding protein) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter.
- 3 · How drugs use it
No product in this corpus aims at CNBP yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:13164 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62633 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169714 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression. Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. Binds G-rich elements in target mRNA coding sequences. Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs. Binds to RNA. Location: Nucleus; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 3q21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CNBP" OR ABSTRACT:"CNBP" OR TITLE:"CCHC-type zinc finger nucleic acid binding protein" OR ABSTRACT:"CCHC-type zinc finger nucleic acid binding protein" OR TITLE:"RNF163" OR ABSTRACT:"RNF163" OR TITLE:"ZCCHC22" OR ABSTRACT:"ZCCHC22" OR TITLE:"CNBP1" OR ABSTRACT:"CNBP1" OR TITLE:"DM2" OR ABSTRACT:"DM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNBP, not a curated reading list.