CNKSR2
CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May function as an adapter protein or regulator of Ras signalling pathways.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.97, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CNKSR2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:19701 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WXI2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000149970 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus Xp22.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CNKSR2" OR ABSTRACT:"CNKSR2" OR TITLE:"connector enhancer of kinase suppressor of Ras 2" OR ABSTRACT:"connector enhancer of kinase suppressor of Ras 2" OR TITLE:"Connector enhancer of kinase suppressor of ras 2" OR ABSTRACT:"Connector enhancer of kinase suppressor of ras 2" OR TITLE:"KIAA0902" OR ABSTRACT:"KIAA0902" OR TITLE:"CNK2" OR ABSTRACT:"CNK2" OR TITLE:"KSR2" OR ABSTRACT:"KSR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CNKSR2, not a curated reading list.