CSF2RB
CSF2RB (Cytokine receptor common subunit beta) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Sarcomas, Leukaemia, Myeloproliferative neoplasms and 1 more.
Overview
Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signalling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Doxorubicin. Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.67, animal model 0.45, genetic association 0.00, clinical 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CSF2RB (Cytokine receptor common subunit beta) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Sarcomas, Leukaemia, Myeloproliferative neoplasms and 1 more.
- 1 · What it is
CSF2RB (Cytokine receptor common subunit beta) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Sarcomas, Leukaemia, Myeloproliferative neoplasms and 1 more.
- 2 · What goes wrong in cancer
Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells.
- 3 · How drugs use it
No product in this corpus aims at CSF2RB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2436 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P32927 (protein name, function text, keywords and locations (REST API)); CIViC gene CSF2RB (1 evidence items, 0 assertions, 1 variants; diseases: Sarcoma (GraphQL API, CC0)); Open Targets ENSG00000100368 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.52, myeloproliferative neoplasm 0.53, leukaemia 0.54 (GraphQL API, CC0))
Biology
Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signalling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. Location: Membrane (UniProt). Locus 22q12.3 (HGNC).
- Sarcomas: CIViC evidence names this disease
- Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)
- Acute myeloid leukaemia: Open Targets association 0.52 with acute myeloid leukaemia (MONDO_0018874)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CSF2RB" OR ABSTRACT:"CSF2RB" OR TITLE:"colony stimulating factor 2 receptor subunit beta" OR ABSTRACT:"colony stimulating factor 2 receptor subunit beta" OR TITLE:"Cytokine receptor common subunit beta" OR ABSTRACT:"Cytokine receptor common subunit beta" OR TITLE:"IL5RB" OR ABSTRACT:"IL5RB" OR TITLE:"CD131" OR ABSTRACT:"CD131" OR TITLE:"betaGMR" OR ABSTRACT:"betaGMR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSF2RB, not a curated reading list.
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