CSNK1A1
CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.89, genetic association 0.17, somatic mutation 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins.
- 3 · How drugs use it
No product in this corpus aims at CSNK1A1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:2451 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P48729 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113712 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Biology
Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus speckle (UniProt). Locus 5q32 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CSNK1A1" OR ABSTRACT:"CSNK1A1" OR TITLE:"casein kinase 1 alpha 1" OR ABSTRACT:"casein kinase 1 alpha 1" OR TITLE:"Casein kinase I isoform alpha" OR ABSTRACT:"Casein kinase I isoform alpha" OR TITLE:"CK1" OR ABSTRACT:"CK1" OR TITLE:"CK1a" OR ABSTRACT:"CK1a" OR TITLE:"CK1alpha" OR ABSTRACT:"CK1alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CSNK1A1, not a curated reading list.