CTSH
CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Important for the overall degradation of proteins in lysosomes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.93, animal model 0.81, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CTSH yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2535 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09668 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103811 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt). Locus 15q25.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CTSH" OR ABSTRACT:"CTSH" OR TITLE:"cathepsin H" OR ABSTRACT:"cathepsin H" OR TITLE:"Pro-cathepsin H" OR ABSTRACT:"Pro-cathepsin H" OR TITLE:"ACC-4" OR ABSTRACT:"ACC-4" OR TITLE:"ACC-5" OR ABSTRACT:"ACC-5" OR TITLE:"ACC4" OR ABSTRACT:"ACC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTSH, not a curated reading list.