CYP11B1
CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
Overview
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.27, animal model 0.54, genetic association 0.00, clinical 0.83).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
- 1 · What it is
CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.
- 2 · What goes wrong in cancer
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids.
- 3 · How drugs use it
No product in this corpus aims at CYP11B1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2591 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15538 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160882 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: renal cell carcinoma 0.52 (GraphQL API, CC0))
Biology
A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyses the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Location: Mitochondrion inner membrane (UniProt). Locus 8q24.3 (HGNC).
- Renal cell carcinoma: Open Targets association 0.52 with renal cell carcinoma (MONDO_0005086)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CYP11B1" OR ABSTRACT:"CYP11B1" OR TITLE:"cytochrome P450 family 11 subfamily B member 1" OR ABSTRACT:"cytochrome P450 family 11 subfamily B member 1" OR TITLE:"Cytochrome P450 11B1, mitochondrial" OR ABSTRACT:"Cytochrome P450 11B1, mitochondrial" OR TITLE:"P450C11" OR ABSTRACT:"P450C11" OR TITLE:"CPN1" OR ABSTRACT:"CPN1" OR TITLE:"CYP11B" OR ABSTRACT:"CYP11B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP11B1, not a curated reading list.