CYP2D6
CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
Overview
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA).
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 1 · What it is
CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
- 2 · What goes wrong in cancer
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids.
- 3 · How drugs use it
No product in this corpus aims at CYP2D6 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2625 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10635 (protein name, function text, keywords and locations (REST API)); CIViC gene CYP2D6 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
Biology
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolises endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signalling. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 22q13.2 (HGNC).
- Breast cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CYP2D6" OR ABSTRACT:"CYP2D6" OR TITLE:"cytochrome P450 family 2 subfamily D member 6 gene/pseudogene" OR ABSTRACT:"cytochrome P450 family 2 subfamily D member 6 gene/pseudogene" OR TITLE:"Cytochrome P450 2D6" OR ABSTRACT:"Cytochrome P450 2D6" OR TITLE:"CPD6" OR ABSTRACT:"CPD6" OR TITLE:"P450-DB1" OR ABSTRACT:"P450-DB1" OR TITLE:"CYP2D" OR ABSTRACT:"CYP2D") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP2D6, not a curated reading list.