DAZAP1
DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
Overview
RNA-binding protein, which may be required during spermatogenesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
- 1 · What it is
DAZAP1 (DAZ-associated protein 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Mantle cell lymphoma.
- 2 · What goes wrong in cancer
RNA-binding protein, which may be required during spermatogenesis. Location: Cytoplasm; Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at DAZAP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2683 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EP5 (protein name, function text, keywords and locations (REST API)); CIViC gene DAZAP1 (1 evidence items, 0 assertions, 1 variants; diseases: Mantle Cell Lymphoma (GraphQL API, CC0))
Biology
RNA-binding protein, which may be required during spermatogenesis. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.3 (HGNC).
- Mantle cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DAZAP1" OR ABSTRACT:"DAZAP1" OR TITLE:"DAZ associated protein 1" OR ABSTRACT:"DAZ associated protein 1" OR TITLE:"DAZ-associated protein 1" OR ABSTRACT:"DAZ-associated protein 1" OR TITLE:"MGC19907" OR ABSTRACT:"MGC19907") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DAZAP1, not a curated reading list.
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