DDR2 receptor kinase
DDR2 is a receptor that senses collagen; mutations in it occur in a small share of squamous lung cancers, and dasatinib inhibits it.
Overview
Discoidin domain receptor 2 is a receptor tyrosine kinase activated by fibrillar collagen rather than by a growth factor. DDR2 mutations were found in around 4 percent of squamous non-small cell lung cancers, and the leukaemia drug dasatinib inhibits DDR2 strongly, which prompted trials in DDR2-mutant lung cancer; responses were seen but the approach did not reach approval.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DDR2 is a receptor that senses collagen; mutations in it occur in a small share of squamous lung cancers, and dasatinib inhibits it.
- 1 · What it is
DDR2 is a receptor that senses collagen; mutations in it occur in a small share of squamous lung cancers, and dasatinib inhibits it.
- 2 · What goes wrong in cancer
Collagen binding through the discoidin domain triggers slow, sustained kinase activation, regulating cell adhesion, migration and matrix remodelling.
- 3 · How drugs use it
No product in this corpus aims at DDR2 receptor kinase yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Biology
Collagen binding through the discoidin domain triggers slow, sustained kinase activation, regulating cell adhesion, migration and matrix remodelling.
- Squamous non-small cell lung cancer (a small mutated subset)
- Fibroblasts and stromal cells
How often this target appears
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Non-small-cell lung cancer | 3.8% | DDR2 kinase mutation, Sanger sequencing of squamous cell lung cancers and cell lines | Squamous histology only; mutant cell lines and one patient responded to dasatinib | doi.org |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Latest papers
topQuery for this target: (TITLE:"DDR2 receptor kinase" OR ABSTRACT:"DDR2 receptor kinase" OR TITLE:"DDR2" OR ABSTRACT:"DDR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDR2 receptor kinase, not a curated reading list.