DDR2 receptor kinase
DDR2 is a receptor that senses collagen; mutations in it occur in a small share of squamous lung cancers, and dasatinib inhibits it. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Collagen binding through the discoidin domain triggers slow, sustained kinase activation, regulating cell adhesion, migration and matrix remodelling.
- Squamous non-small cell lung cancer (a small mutated subset)
- Fibroblasts and stromal cells
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsHow common it is in each cancer
Full matrix →| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Non-small-cell lung cancer | 3.8% | DDR2 kinase mutation, Sanger sequencing of squamous cell lung cancers and cell lines | Squamous histology only; mutant cell lines and one patient responded to dasatinib | doi.org |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Products by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"DDR2 receptor kinase" OR ABSTRACT:"DDR2 receptor kinase" OR TITLE:"DDR2" OR ABSTRACT:"DDR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDR2 receptor kinase, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ddr2.json. Licence CC BY-NC 4.0.