DEK
DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
Overview
Involved in chromatin organisation.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
- 1 · What it is
DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
- 2 · What goes wrong in cancer
Involved in chromatin organisation. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at DEK yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2768 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35659 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124795 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: gastric cancer 0.51, breast cancer 0.53 (GraphQL API, CC0))
Biology
Involved in chromatin organisation. Location: Nucleus (UniProt). Locus 6p22.3 (HGNC).
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DEK" OR ABSTRACT:"DEK" OR TITLE:"DEK proto-oncogene" OR ABSTRACT:"DEK proto-oncogene" OR TITLE:"D6S231E" OR ABSTRACT:"D6S231E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DEK, not a curated reading list.