DNAJB1
DNAJB1 (DnaJ homolog subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.85, genetic association 0.00, somatic mutation 0.90).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DNAJB1 (DnaJ homolog subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
DNAJB1 (DnaJ homolog subfamily B member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region.
- 3 · How drugs use it
No product in this corpus aims at DNAJB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5270 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25685 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132002 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70-dependent folding process by interacting with the HSP70 amino terminal region. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro). Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 19p13.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DNAJB1" OR ABSTRACT:"DNAJB1" OR TITLE:"DnaJ heat shock protein family Hsp40 member B1" OR ABSTRACT:"DnaJ heat shock protein family Hsp40 member B1" OR TITLE:"DnaJ homolog subfamily B member 1" OR ABSTRACT:"DnaJ homolog subfamily B member 1" OR TITLE:"Hsp40" OR ABSTRACT:"Hsp40" OR TITLE:"Sis1" OR ABSTRACT:"Sis1" OR TITLE:"RSPH16B" OR ABSTRACT:"RSPH16B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAJB1, not a curated reading list.