EBF2
EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.36, animal model 0.53, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway.
- 3 · How drugs use it
No product in this corpus aims at EBF2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:19090 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HAK2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000221818 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"EBF2" OR ABSTRACT:"EBF2" OR TITLE:"EBF transcription factor 2" OR ABSTRACT:"EBF transcription factor 2" OR TITLE:"Transcription factor COE2" OR ABSTRACT:"Transcription factor COE2" OR TITLE:"FLJ11500" OR ABSTRACT:"FLJ11500" OR TITLE:"COE2" OR ABSTRACT:"COE2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EBF2, not a curated reading list.